NeuroGen Brain and Spine Institute, India
Keynote: J Neurol Neurophysiol
Stem cell therapy has shown great potential as a treatment strategy for neurological disorders. Autologous bone marrow mononuclear cells have shown a positive outcome in these disorders due to their obtainability, safety and efficacy. In autism, out of 32, 92% cases showed improved social interaction, emotional response, speech and communication, behavior, cognition and sensory aspect on ISAA, CGI and FIM/WeeFIM. In cerebral palsy, 95% out of 40 patients showed improvements in oromotor activities, neck control, sitting balance, standing, walking balance and speech. These improvements correlated with improved brain metabolism recorded in the PET CT scan. In spinal cord injury, 91% out of 110 patients in thoracolumbar SCI and 74% out of 56 patients with cervical SCI showed improvement in spasticity, sensation, trunk control, bladder management, standing and sitting balance, ambulation and ADLs. Changes were recorded in ASIA, FIM scale and electrophysiological studies. In head injury, 93% out of 14 cases showed improvement in balance, voluntary control, muscle tone, memory, oromotor activities, cognition, coordination, speech, communication, ambulation and ADLs. In muscular dystrophy, 86.67% out of 150 showed improved strength in trunk, upper and lower limbs alongwith gait. 6 patients demonstrated muscle regeneration on musculoskeletal MRI and 9 showed improvement in EMG. In ALS, as compared to the control population (n=20), the survival duration of the treated population (n=37) increased by 30.38 months. In Stroke, improvements were observed in ambulation, hand function and standing and walking balance with ischemic stroke demonstrating better recovery than hemorrhagic stroke. No major adverse events were reported.
Alok Sharma is a Neurosurgeon and presently Professor & Head of Department of Neurosurgery at the LTMG Hospital & LTM Medical College and the Director of the NeuroGen Brain & Spine Institute and Consultant Neurosurgeon at the Fortis Hospital in Mumbai, India. He has authored 12 books, edited 2 books, contributed chapters to 8 other books and has 83 scientific publications in medical journals. He has made 146 scientific c presentations all over the world & has conducted several national and international trials and has been conferred with numerous honors and awards in his distinguished career. He has organized many international and national conferences and regularly conducts hands-on training workshops on Micro vascular Surgery, Neuro endoscopy and Spinal fixations. He has been committed to both basic as well as clinical research in attempting to find an answer to the problems of paralysis and neurological deficits that occur following injury and diseases of the nervous system. Is the pioneer of Stem cell therapy in India and has setup the Stem cell and Genetic research laboratory at the LTMG hospital & LTM Medical College. He has also created the NeuroGen Brain and Spine institute which is India’s first dedicated Stem Cell Therapy and Neurorehabilitation Hospital. He has published path breaking results of Stem Cell therapy in Pediatric Neuro developmental disorders such as Autism and Cerebral palsy as well as in other conditions such as Muscular dystrophy and Spinal cord injury. He is the founder of the “Indian Journal of Stem Cell Therapy” and on the editorial board of 4 other journals. He is the Founding President of the “Stem Cell Society of India” and the Vice President of the “International Association of Neurorestoratology”. His other special interests include Revascularization surgery for cerebral ischemia, Psychosurgery, Stereotactic surgery, Neuroendoscopy, Spinal surgery and Neurotrauma.