Yasaman Razavi, Mehdi Mehdizadeh and Abbas haghparast
University of Medical Sciences, Tehran, Iran
Shahid Beheshti University of Medical Sciences, Iran
Posters & Accepted Abstracts: J Neurol Neurophysiol
Methamphetamine is a highly addictive drug of abuse, addiction to which has increased to epidemic proportions worldwide. It has been suggested that chronic use of Meth causes long-term cognitive deficits. Furthermore, Cannabidiol (CBD) has a large-spectrum therapeutic potential to treat many neuropsychiatric disorders, such as addiction. Several studies have indicated that learning and memory, and particularly contextual memories, play a critical role in establishing conditioned responses in addiction. The aim of the present study was to investigate the effects of CBD treatment after addicted Meth on two hippocampus-dependent memory tasks: Novel Object Recognition as a non-spatial memory task and Y maze as a spatial memory task. Male rats were addicted to Meth (twice, 2.0 mg/kg, s.c.) for 10 days, Then, we evaluated the effect of CBD (50 μg/5 μl; ICV) on spatial working memory, by using the Y maze test, and recognition memory, by using novel object recognition test (NORT), on extinction period (10 days). we found Meth-induced impairment in memory performance whereas CBD could improve the effect of Meth destruction also chronic METH had deficit effect on spontaneous behavior and recognition memory impairment obviously seen in METH group compared to control group in Novel Objective test, more ever CBD administration could reverse long-term memory.in conclusion CBD can be considered an agent that Reinforce learning and memory system, however, this requires more investigation.
Yasaman Razavi is a PhD student in Neuroscience. The study was conducted to investigate “Effect of cannabidiol on behavior, histological, and gene expression changes related to methamphetamine-addicted.” She is post graduated in cellular and molecular biology. Currently she is working with Dr. Haghparast Lab, Neuroscience Research Center in Shahid Beheshti University of Medical Sciences. She has 10 published article on her name.
E-mail: razavi.yasaman@gmail.com
