Victor Manolov, Savina Hadjidekova, Julia Petrova, Vasil Vasilev, Maria Petrova, Yavor Jelev, Todor Kunchev, Petar Jeliazkov, Kamen Tzatchev and Latchezar Traykov
Medical University in Sofia, Bulgaria
Posters & Accepted Abstracts: J Neurol Neurophysiol
Hepcidin leads to the deposition of iron in macrophages in atherosclerotic plaques by an increase in lipid peroxidation and progression of foam cells, which leads to the risk of atherosclerosis. Mini-Mental State Examination (MMSE) and Isaakâ��s test are sensitive ways for early cognitive function evaluation. 23 patients [10 females (43.5%)] with suspected atherosclerosis were included. They were clinically and neurologically reviewed, EMG; IMT and ABI were measured. They were evaluated for routine biochemical parameters, and additional serum hepcidin were quantified. AAS, nephelometric, ELISA and statistical methods were used during analyzes and obtained results interpretation. All results were compared to age and gender matched healthy controls. We found statistically significant elevated serum hepcidin in patients suspected for atherosclerosis (52.9�±3.9 �¼g/L) compared to healthy controls (21.6�±3.4 �¼g/L); P<0.001. Patients suspected for atherosclerosis showed deviations of Mini-Mental State Examination (MMSE) and Isaakâ��s test, which correlates to increased hepcidin concentration. Our findings suggest serum hepcidin quantification as a marker for iron deposition in suspected atherosclerosis and early diagnosis of atherosclerotic changes.
Email: victhedoc3@mail.bg
