Application of 18F-FDG PET/CT in detection of transformation of s | 48717

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Application of 18F-FDG PET/CT in detection of transformation of small lymphocytic lymphoma/chronic lymphocytic leukemia

7th Global Neurologists Annual Meeting on Neuro Surgery and Interventional Radiology

August 22-24, 2016 Vienna, Austria

Jianhua Zhang

Peking University First Hospital, China
Peking University International Hospital, China

Scientific Tracks Abstracts: J Neurol Neurophysiol

Abstract :

Richterâ??s transformation (RT, Richterâ??s syndrome) was first described by Maurice Richter as the development of an aggressive large-cell lymphoma in the setting of underlying small lymphocytic lymphoma /chronic lymphocytic leukemia (SLL/CLL). We try to investigate the role of in detection of RT of SLL/CLL. Twelve patients with SLL/CLL underwent 18F-FDG PET/CT between Jul 2010 and Nov 2015 were retrospectively analyzed. FDG avid lesions with a maximum standardized uptake value (SUVmax) of greater than 5 were considered highly suggestive of RT. The diagnosis of RT was based on the histopathological examination. All patients (8 males and 4 females) had the history of SLL/CLL ranged from 2 years to 11 years. Four patients underwent RT to diffuse large B-cell lymphoma, PET/CT detected sites of increased FDG uptake with SUVmax ï¼?5 in 3 patients(3/4, 75%), 1 patient has false-negative PET/CT findings. No patient had false-positive PET/CT findings and PET/CT correctly excluded RT in the other 8 patients. The overall sensitivity, specificity and accuracy of PET/CT for RT of SLL/CLL were 75%, 100% and 91.6%, respectively. According to the preliminary data, 18F-FDG PET/CT has high accuracy for detection of RT of SLL/CLL. PET/CT can exclude the diagnosis of RT with a high degree of confidence in patients with SLL/CLL.

Biography :

Jianhua Zhang has completed his M.S. in 2004 and M.D. studies in 2012 from Peking University, majoring in Radiology and Nuclear Medicine. He joined the faculty of nuclear medicine at Peking University First 2004 and now is the associate professor. He has published more than 20 papers in journals and 20 chapters in proceedings and medical textbooks. The research interests of Dr. Zhang include application of positron emission tomography (PET) in studies of tumors, especially the lymphoma, and quantitve analysis. He has been involved in teaching of more than 30 residents.