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Antioxidants attenuate isolation and L-DOPA Induced aggression in mice

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Antioxidants attenuate isolation and L-DOPA Induced aggression in mice

Joint Event on International Conference on Neuroimmunology, Neurological disorders and Neurogenetics & 28th World Summit on Neurology, Neuroscience and Neuropharmacology

September 26-27, 2018 | Montreal, Canada

Sundas Hira

Riphah International University, Pakistan

Posters & Accepted Abstracts: J Neurol Neurophysiol

Abstract :

Aggression is a highly conserved and destructive behavior with an intention to cause harm. Aggression is associated with negative traits such as choler, impulsivity, perturbation, and proneness to violence. Antioxidants have been used for the treatment of many ailments for many years. The present study was carried out on Swiss male albino mice to explore the role of antioxidants at two dose levels, such as ascorbic acid (15.42 and 30.84 mg/kg), beta-carotene (1.02 and 2.05 mg/kg), vitamin E (2.5 and 5.0 mg/kg), and N-acetyl cysteine (102.85 and 205.70 mg/kg) in the treatment of aggression. Aggression was induced by putting mice into artificial situations (isolating animals for one month and administration of L-DOPA). Swiss male albino mice (n = 330) were divided into 11 groups (Group I-control, group II-diseased, group III-standard group, group IV‚??V treated with ascorbic acid, group VI-VII treated with beta-carotene, group VIII‚??IX treated with vitamin E, group X‚??XI treated with N-acetyl cysteine for 14 consecutive days). Endogenous antioxidants (glutathione, superoxide dismutase, and catalase) were analyzed to determine the antioxidant potential in oxidative stress. In isolated animals, high dose of vitamin E (5.0 mg/kg) was found to be more potent to placate the mice while all other antioxidants produced dose-dependent anti-aggressive effect except N-acetyl cysteine which had pronounced anti-aggressive effect at the low dose (102.75 mg/kg). In acute anti-aggressive activity against L-DOPA induced aggression, low doses of vitamin E (2.5 mg/kg) and N-acetyl cysteine (102.75 mg/kg) and the high dose of beta-carotene (2.05 mg/kg) were effective to avert all aggression parameters. However, all test antioxidants were equally effective in chronic anti-aggressive studies against L-DOPA induced aggression. It may be concluded that selected antioxidants can alleviate the aggression which is a prodrome of much neurological disorder such as schizophrenia etc.

Biography :

E-mail: [email protected]

 

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