Anti-2-glycoprotein I autoantibody expression as a potential biom | 49955

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Anti-2-glycoprotein I autoantibody expression as a potential biomarker for strokes in patients with anti-phospholipid syndrome

13th World Conference on Neurology and Neuromuscular Disorders

October 01-02, 2018 | Frankfurt, Germany

Husham Bayazed and Abdullah A Z

University of Zakho, Iraq
University of Mosul, Iraq

Scientific Tracks Abstracts: J Neurol Neurophysiol

Abstract :

Anti-phospholipid syndrome (APS) is an autoimmune disease. Cerebral ischemia associated with APS occurs at a younger age than typical atherothrombotic cerebrovascular disease, is often recurrent and is associated with high positive IgG antiphospholipid (GPL) unit levels. This study sought to determine the frequency rates of anti-cardiolipin (aCL) dependent on the presence of β2-GPI, anti-β2-glycoprotein I (aβ2-GPI) and anti-phosphatidyl serine (aPS) IgG autoantibodies among stroke patients and thus demonstrate the importance of testing for aβ2-GPI autoantibodies. Stroke patients and control subjects recruited from Mosul, Erbil and Dohuk provinces in Northern Iraq were evaluated. All cases were under 50 years-of-age and had no recognizable risk factors. ELISA was used to evaluate the presence of IgG isotype of aCL, aβ2-GPI, and aPS autoantibodies in their blood, the results indicated that the frequency of aβ2-GPI was 14/50 (28%), aCL was 11/50 (22%) and aPS was 9/50 (18%) among stroke patients. In contrast, aCL was detected in 2/30 (6.7%) of control subjects; each of the other anti-phospholipid antibodies (APLA) was never observed. Of all the aβ2-GPI+ cases, the incidence of stroke patients having the combined profile of aβ2-GPI+aCL was 11/14 (78.6%) and of aβ2-GPI+aPS was 9/14 (64.3%) only 2/14 (14.3%) of these aβ2-GPI+ patients expressed aCL in the absence of aPS. The frequency of patients expressing all three markers was only 9/14 (64.3 %). In none of the APS/stroke patients were aCL or aPS expressed in the absence of the aβ2-GPI. Conversely, IgG aβ2- GPI as a sole marker was seen in 3/14 (21.4%) of these patients (i.e. in absence of either other marker). It can be concluded from these studies that among the three major forms of APLA examined, the presence of IgG aβ2-GPI autoantibodies appeared to correlate best with stroke in patients who were concurrently suffering from APS. Recent Publications 1. Husham Bayazed (2012) Concentration levels of IL-10 and TNFα cytokines in patients with human papilloma virus (HPV) DNA+ and DNA?? cervical lesions. Journal of Immunotoxicology (USA). 2012; 9: 168-172. 2. Husham Bayazed (2014) Assessment of Chlorine Resistant Bacteria and their Susceptibility to Antibiotics from Water Distribution System in Duhok Province/ Kurdistan. Journal of Applied Biology and Biotechnology vol.2 (06), pp, 010- 013; Nov-Dec, 2014. 3. Husham Bayazed (2007) The Role of Antiphospholipid Autoantibodies Syndrome in Cerebrovascular Diseases. Qatar Medical Journal 2007; 16(2): 41-46. 4. Husham Bayazed (2014) Detection of human papillomavirus DNA in patients with different cervical lesions in Kurdistan Region, Iraq. European Journal of Cancer, 48: 4s -5s 2014.

Biography :

Husham Bayazed has completed his PhD at University of Mosul, College of Medicine. He is now a Consultant at the Scientific Research Center, University of Zakho/Kurdistan Region, Iraq. He is a Specialist and Consultant in Microbiology and Immunology and has published more than 25 papers in reputed journals and has been serving as a Scientific Reviewer for many local and international medical journals. In addition, he has a Fellowship of ISC, Infection, Cancer, Immunology Advisory Board Member (EUROMDnet) Belgium, Membership of World Stroke Organization, Membership of Metabolomics, USA, and Membership of American Association of Science & Technology with more than 20 participations in international scientific meetings all over the world.