Amyloid-beta regulation in Alzheimer’s disease | 48061

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Amyloid-beta regulation in Alzheimer’s disease

2nd International Conference and Exhibition on Neurology & Therapeutics

June 17-19, 2013 Hilton Chicago/Northbrook, Chicago, USA

Robert A. Marr

Scientific Tracks Abstracts: J Neurol Neurophysiol

Abstract :

T he amyloid-beta (A β ) peptide remains an intensely studied factor in Alzheimer?s disease (AD) as genetic studies continue to implicate this peptide in disease pathogenesis. A β is produced by the proteolytic processing of the amyloid- β precursor protein (APP) by beta secretase and presenilin associated gamma secretase activities. All known familial-AD causing mutations are in APP as well as the presenilins and increase the production, accumulation, or aggregation of A β . In the more common sporadic form of AD, clinical evidence implicates reduced clearance of A β rather than increased production in disease pathogenesis. Neprilysin (NEP) has been shown to be a critical A β -degrading enzyme; however, evidence suggests that other ?NEP-like? enzymes are also contributing to clearance of A β . We have shown that the NEP homolog NEP2 can degrade A β and is important for the control of A β levels in vivo . We have also found that NEP2 expression and activity may be dysregulated early in AD pathogenesis. This work has implications for the development of molecular markers of AD and for the development of NEP2 augmentation for AD therapy. Also, for therapy, the induction of reduced A β production is an obvious therapeutic objective. Recently we have shown that stimulation of the Reelin pathway through F-spondin gene transfer can reduce A β levels and ameliorate AD-like pathology in mice.

Biography :

Marr completed his Ph.D. at the age of 29 years from McMaster University and went on to do his postdoctoral studies at the Salk Institute for Biological Studies. He has been an Assistant Professor of Neuroscience at Rosalind Franklin University of Medicine and Science since 2005. He has published 30 papers in reputed journals and has received funding from the Alzheimer?s Association, Alzheimer?s Drug Discovery Foundation, and the Schweppe Foundation.