Journal of Health and Medical Research

Prion Diseases

Prions are misfolded proteins with the facility to transmit their misfolded shape onto mundane variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It is not kenned what causes the mundane protein to misfold, but the anomalous three-dimensional structure is suspected of conferring infectious properties, collapsing nearby protein molecules into the same shape. The word prion derives from "proteinaceous infectious particle".The hypothesized role of a protein as an infectious agent stands in contrast to all other kenned infectious agents such as viruses, bacteria, fungi and parasites, all of which contain nucleic acids (DNA, RNA or both). Prion variants of the prion protein , whose concrete function is dubious, are hypothesized as the cause of transmissible spongiform encephalopathies (TSEs), including scrapie in sheep, chronic wasting disease (CWD) in deer, bovine spongiform encephalopathy (BSE) in cattle (commonly kenned as "mad cow disease") and Creutzfeldt–Jakob disease (CJD) in humans. All kenned prion diseases in mammals affect the structure of the encephalon or other neural tissue; all are progressive, have no kenned efficacious treatment and are always fatal.Until 2015, all kenned mammalian prion diseases were considered to be caused by the prion protein (PrP); however in 2015 multiple system atrophy (MSA) was hypothesized to be caused by a prion form of alpha-synuclein.Prions form anomalous aggregates of proteins called amyloids, which accumulate in infected tissue and are associated with tissue damage and cell death. Amyloids are additionally responsible for several other neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.Prion aggregates are stable, and this structural stability betokens that prions are resistant to denaturation by chemical and physical agents: they cannot be ravaged by mundane disinfection or cooking. This makes disposal and containment of these particles arduous. To increment the overtness and facilitate of avail of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving accommodations. Indexing provides facile access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are paramount for a journal to get impact factor. Impact factor is a quantification reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more paramount than those with lower ones. Indexing provides facile access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, pertinent and reliable information predicated on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated utilizing citations not only from research articles but adscititiously review articles (which incline to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and endeavor to increment their number expeditiously. Impact factor plays a major role for the particular journal.

Relevant Topics in Medical Sciences