Neurons are the building blocks of the nervous system which includes the encephalon and spinal cord. Neurons mundanely dont reproduce or supersede themselves, so when they become damaged or die they cannot be superseded by the body. Examples of neurodegenerative diseases include Parkinsons, Alzheimers, and Huntington disease. Neurodegenerative diseases are incurable and debilitating conditions that result in progressive degeneration and / or death of nerve cells. This causes quandaries with kineticism (called ataxias), or noetic functioning (called dementias).Dementias are responsible for the greatest encumbrance of neurodegenerative diseases, with Alzheimers representing approximately 60-70% of dementia cases. Neurons are the building blocks of the nervous system which includes the encephalon and spinal cord. Neurons customarily reproduce or supersede themselves, so when they become damaged or die they cannot be superseded by the body. Examples of neurodegenerative diseases include Parkinson, Alzheimers, and Huntington disease. Neurodegenerative diseases are incurable and debilitating conditions that result in progressive degeneration and / or death of nerve cells. This causes quandaries with kineticism (called ataxias), or noetic functioning (called dementias).Dementias are responsible for the greatest encumbrance of neurodegenerative diseases, with Alzheimer representing approximately 60-70% of dementia cases. HD causes astrogliosis and loss of medium spiny neurons. Areas of the encephalon are affected according to their structure and the types of neurons they contain, abbreviating in size as they cumulatively lose cells. The areas affected are mainly in the striatum, but withal the frontal and temporal cortices. The striatum's subthalamic nuclei send control signals to the globus pallidus, which initiates and modulates kineticism. The more impuissant signals from subthalamic nuclei thus cause abbreviated initiation and modulation of kineticism, resulting in the characteristic forms of kineticism of the disorder, eminently chorea. Mutant Huntingtin is an aggregate-prone protein. During the cells' natural clearance process, these proteins are retrogradely conveyed to the cell body for eradication by lysosomes. It is a possibility that these mutant protein aggregates damage the retrograde convey of paramount cargoes such as BDNF, by damaging molecular motors as well as microtubules. To increase the visibility and ease of use of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving services. Indexing provides easy access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports.