Despondence is relegated as a mood disorder. It may be described as feelings of woebegoneness, loss, or anger that interfere with a person everyday activities. It withal fairly mundane. The Centers for Disease Control and Obviation (CDC)Trusted Source estimates that 8.1 percent of American adults ages 20 and over had melancholy in any given 2-week period from 2013 to 2016. People experience despondence in different ways. It may interfere with your circadian work, resulting in lost time and lower productivity. It can additionally influence relationships and some chronic health conditions. It paramount to realize that feeling down at times is a mundane part of life. Doleful and upsetting events transpire to everyone. But, if you feeling down or hopeless on a customary substratum, you could be dealing with dejection. Melancholy is considered an earnest medical condition that can get worse without congruous treatment. Those who seek treatment often visually perceive amendments in symptoms in just a few weeks. Despondence can be more than a constant state of woefulness or feeling. Major dejection can cause a variety of symptoms. Some affect your mood, and others affect your body. Symptoms may withal be perpetual, or come and go. The symptoms of melancholy can be experienced differently among men, women, and children differently. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly. Impact factor plays a major role for the particular journal.