Chromatin is a complex of DNA and protein found in eukaryotic cells. Its primary function is packaging long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in reinforcing the DNA during cell division, preventing DNA damage, and regulating
gene expression and DNA replication. During mitosis and meiosis,
chromatin facilitates proper segregation of the chromosomes in anaphase; the characteristic shapes of chromosomes visible during this stage are the result of DNA being coiled into highly condensed chromatin. Many organisms, however, do not follow this organization scheme. For example, spermatozoa and avian red blood
cells have more tightly packed
chromatin than most eukaryotic cells, and trypanosomatid protozoa do not condense their
chromatin into visible chromosomes at all. Prokaryotic
cells have entirely different structures for organizing their DNA (the prokaryotic
chromosome equivalent is called a genophore and is localized within the nucleoid region).The overall structure of the
chromatin network further depends on the stage of the cell cycle. During interphase, the
chromatin is structurally loose to allow access to RNA and DNA polymerases that transcribe and replicate the DNA. The local structure of
chromatin during interphase depends on the specific genes present in the DNA. Regions of DNA containing genes which are actively transcribed ("turned on") are less tightly compacted and closely associated with RNA polymerases in a structure known as euchromatin, while regions containing inactive genes ("turned off") are generally more condensed and associated with structural proteins in heterochromatin. Epigenetic modification of the structural proteins in
chromatin via methylation and acetylation also alters local
chromatin structure and therefore gene expression. The structure of
chromatin networks is currently poorly understood and remains an active area of research in molecular biology.
Relevant Topics in Nursing & Health Care
