Department of Traditional Medicine, Inner Mongolia Medical University, Hohhot, China
Research Article
Study on Bone Protection Mechanism of Zuogui Pill on Osteoporosis Model of Breast Cancer Rats after Endocrine Therapy
Author(s): Liu Chunhui*, Ao Youguang, Yao Lei, Zhou La, Jiang Zhaolei, Ma Jianchao and Shen Zhuorui
Introduction: Clinic however, the possible mechanism of bone protection mechanism of Zuogui pill on osteoporosis is still largely unknown.
Methods: An osteoporosis model of postmenopausal breast cancer was generated by gavage of letrozole in mice with ovariectomized breast cancer. Female SPF BALB/c mice were divided into the normal group, pseudocastrated group, model group (letrozole), alendronate group (alendronate tablets) and lowdose, medium-dose and high-dose Zuogui pill groups. Each group was given gavage for 4 weeks according to the corresponding administration plan. Blood was collected from the eyeballs. Serum oestradiol (E2), Bone Alkaline Phosphatase (BALP) and amino terminal propeptide of type ? collagen (PINP) were detected by Enzyme-Related Immunosorbent Assays (ELISAs). After death, the right femur and tibia were taken and stain.. View More»
DOI:
10.35248/2322-3308-12.5.001
