Sensorimotor Integration Lab, Orbeli Institute of Physiology, NASRA, Yerevan, Armenia
Research Article
Functional, Behavioral and Morphological Changes in the Rat Model of Parkinson's Disease: Protective Effect of Curcumine
Author(s): L.V Darbinyan*, L.E Hambardzumyan, L.P Manukyan, K.V Simonyan, S.H Badalyan, N.V Sargsyan and V.H Sarkisian
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects nerve cells, or neurons, in the part of the brain that controls movement. A hallmark feature of PD is the degeneration of the dopamine neurons in the substantia nigra (SN) pars compacta and the consequent striatal dopamine deficiency. Yet, the pathogenesis of PD remains unclear.The lack of dopamine causes the primary symptoms of Parkinson's disease - tremor, slowness of movement, muscle stiffness and balance problems. In vivo animal models have simulated most, although not all, of the hallmarks of PD and are useful for testing new neuroprotective approaches. Research is devoted to the study of systemic compensatory reactions of the rat's brain developing in response to rotenone-induced animal model of PD under the conditions of neuroprotective intervention of Curcumin. This has raising expect.. View More»
