Journal of Biology and Today's World

ISSN - 2322-3308

Saurabh Sharma

Department of Pharmacology, School of Pharmaceutical Sciences, CT University, Ludhiana, India


  • Review Article   
    Insight on Poly (ADP-Ribose) Polymerase (PARP) as a Potential Pharmacological Target in Pathological Conditions
    Author(s): Mandeep Kaur and Saurabh Sharma*

    Recent studies have clearly indicated that Poly (ADP-Ribose) Polymerase (PARP) has an essential role in various physiological and pathophysiological pathways including the signaling of DNA damage, cell death pathways, cell survival and proliferation pathways, differentiation, neuronal function and inflammation. Role of PARP has been established in cardiovascular diseases like myocardial infarction, endothelial dysfunction associated hypertension, ischemia-reperfusion injury. It also plays an important role in the pathophysiology of diabetes, inflammatory disorders, and various neurodegenerative disorders. Approaches in this area lead to the identification of 18 putative PARP sequences in the human genome. PARP-1 is a most abundantly found nuclear protein which functions to sense the DNA damage. Increased oxidative stress due to any pathophysiological c.. View More»
    DOI: 10.35248/2322-3308.21.10.008

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