University of Connecticut, University of Connecticut Health Centre, USA, University of Connecticut Health Centre, USA, Radhika Kulkarni, Meghana Singh, James J Vredenburgh, United States of America
Case Report
CNS Metastasis and Ovarian Carcinoma. Is BRCA Mutation an Ally? - A
Case Report
Author(s): Radhika Kulkarni
Despite advances in medical diagnostics and treatment, ovarian
carcinoma continues to be a disease detected at a late stage when
metastasis has occurred. Ovarian cancer spreads early to the
peritoneum resulting in massive and rapidly accumulating ascites.
Central nervous system metastasis, though rare has been reported.
Here, we report a case of papillary serous carcinoma of the ovary
in a sixty-year-old female who had florid metastasis involving the
brain and the spinal nerve roots. Her cancer was detected when
intra-abdominal spread had occurred; however, she did achieve a
period of clinical remission with chemotherapy and PARP inhibitors.
Her treatment included neo-adjuvant chemotherapy with carboplatin
and paclitaxel, debulking of the tumor, and adjuvant chemotherapy
with carboplatin and docetaxel... View More»