Department of Biotechnology, Graphic Era University, India
Mini Review
Alzheimer's Disease: Oxidative Stress
Author(s): Pragati Singh
Alzheimer's Disease (AD) is the leading cause of impairment among people over the age of 65 across the world. Amyloid (A) peptide deposition abnormalities, the intracellular buildup of hyperphosphorylated protein neurofibrillary tangles, and dementia are all symptoms of Alzheimer's disease. The neurotoxic oligomer A peptide, which is the disease's neuropathological diagnostic criteria, and protein are mediators of neurodegeneration, which is one of the primary causes. However, oxidative stress, which is defined as an imbalance between antioxidants and oxidants that favours oxidants, is the primary cause and aggressor of these symptoms. Increased free radicals or a reduction in antioxidant defence can cause this imbalance. Free radicals are species with one or more unpaired electrons in their outer shell. Understanding the pathophysiology of Alzheimer's disease is becom.. View More»
DOI:
10.35248/2471-268X.22.13.583
