Department of Pathology, Torrance Memorial Medical Center, Torrance, California, United States
Review
Long COVID, POTS, and ME/CFS: Lifting the Fog
Author(s): Patrick Chambers*
These three syndromes - Long Covid (LC), Postural Orthostatic Tachycardia Syndrome (POTS), and Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) have many symptoms in common. The common denominator remains elusive. The Blood Brain Barrier (BBB) has been a barrier not only to microbes and toxins but also to understanding pathogenetic links. There are several areas within the brain that have no BBB. These are known as Circumventricular Organs (CVOs) and their location relative to CNS nuclei that direct autonomic and neuroendocrine functions is provocative in the quest for pathogenesis. In addition the majority afflicted with LC and ME/CFS appear to be those with two MTHFR polymorphisms, present in over 50% of Americans. These polymorphisms elevate homocysteine. When Homocysteine (Hcy) is combined with CVOs, the fog of POTS and its paradox are lifted. POTS may represent the in.. View More»
DOI:
10.35248/2332- 2594.23.14(3).341
