Department of Pharmacology, Pharmacognosy and Botany, Complutense University, Madrid, Spain
Drug-drug interaction of oral antineoplastic agents in the cancer patient.
Author(s): Lara Martín Rizo*, Marta Sánchez Gómez-Serranillos, Marcelo Domínguez Cantero, Luis Carlos Fernández Lisón, Irene Iglesias Peinado and María Pilar Gómez-Serranillos Cuadra
Background: The aim is to describe the potential interactions between oral antineoplastic agents and concomitant medication. Previous studies proved that oral antineoplastic agents are associated with significant drug-drug interactions. Methods: The retrospective observational study to detect the potential interactions drug between oral antineoplastic agents and concomitant medication. All drug interactions detected between concomitant medication and oral antineoplastic agents were recorded. All potential interactions were classified by database as C (monitor therapy), D (consider therapy modification) or X (avoid combination) risk level. The analysis was carried out with three different databases. A descriptive analysis was conducted, including into account the demographic and clinical data, as well as the drug most commonly prescribed in the analyzed treatment. Results: A total de 3.. View More»