Medical Reports & Case Studies

ISSN - 2572-5130

Helly Jones

Editorial Office, Medical Reports and Case Studies, Belgium


  • Mini Review   

    Author(s): Helly Jones*

    Intron 16 of the Angiotensin Converting Enzyme (ACE) gene has an insertion/deletion (I/D) polymorphism of 287 bp Alu repeat sequence, resulting in three genotypes: I/D, D/D, and I/I. The expression of the ACE gene is linked to ACE levels in cells and plasma. It was discovered that the polymorphism could affect the ACE gene's expression. The D/D genotype is thought to have a negative impact on a variety of pathologies, and it may also be a cause-effect for type 2 diabetic nephropathy (T2DN). By comparing the genotype data of T2DN patients to healthy controls, Type 2 diabetes mellitus (T2DM), and nephropathy patients in this study, we were able to determine the frequency of different ACE gene genotypes and see if there is a link between ACE gene polymorphism and T2DN. The Insertion Deletion (ID) polymorphism in intron 1 of the ACE gene is a functional polymorphism that has.. View More»
    DOI: 10.4172/2572-5130.1000180

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