Synapse, Neuroscience Institute, Pakistan
Perspective
Pexophagy and peroxisomes in neurological disorders
Author(s): Hala Abdullateef*
Endoplasmic Reticulum (ERs), lipid bodies, and mitochondria are all in communication with peroxisomes. varied parts of the brain have varied types, sizes, and forms of them. Additionally, peroxisomes are crucial for maintaining oxidative equilibrium, lipid synthesis, and degradation in the Central Nervous System (CNS), and their failure results in a number of neurological disorders. Pexophagy, which is the selective elimination of malfunctioning or unnecessary peroxisomes, has neuroprotective effects, suggesting a possible therapeutic target. However, the role of pexophagy in neurological diseases is mainly unstudied. The mechanisms of pexophagy crosstalk in neurological pathology require more research... View More»
