Yun Jeong Hong
Taiwan
Research Article
Ankle-Brachial Pressure Index and Pulse Wave Velocity as Markers of White Matter Hyperintensities and Cognitive Impairment
Author(s): Yong S Shim, Bora Yoon, Yun Jeong Hong, A-Hyun Cho, Dong Suk Shim, Hae Eun Shin and Dong Won YangYong S Shim, Bora Yoon, Yun Jeong Hong, A-Hyun Cho, Dong Suk Shim, Hae Eun Shin and Dong Won Yang
Vascular disease is associated with cognitive impairment. White matter hyperintensities (WMHs), as detected by
brain magnetic resonance imaging (MRI), are associated with cognitive impairment and considered to be a marker
of cerebral microvascular abnormality. Ankle-brachial pressure index (ABI) and pulse wave velocity (PWV) are noninvasive
methods to assess blockage and stiffness in peripheral arteries, respectively. We investigated the
associations of ABI and PWV with WMHs and cognition. We included 242 subjects representing 56 controls, 75
patients with mild cognitive impairment, and 111 patients with Alzheimer’s disease. We assessed brachial-ankle
PWV (baPWV), ABI, general cognitive status with the Korean Mini-Mental State Examination (K-MMSE), and WMHs
with brain MRI. The mean age of subjects correlated with values of baPWV (.. View More»
