Yuanxia Wu
IR Iran
Research Article
Bone Morphogenetic Proteins are Significantly Reduced in the Follicular
Fluid of Han Chinese Polycystic Ovary Syndrome Patients
Author(s): Junfen Liu, Yuanxia Wu, Suming Xu, Dan Su and Xueqing WuJunfen Liu, Yuanxia Wu, Suming Xu, Dan Su and Xueqing Wu
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 10% of women of childbearing age. Traditionally, androgen elevation has been considered the main pathological cause for PCOS. However, it is increasingly recognized that bone morphogenetic proteins (BMPs), members of the transforming growth factor β (TGF-β) family, play important roles in follicle recruitment, follicle selection, and follicle-stimulating hormone (FSH) responsiveness.
Methods: Twenty-eight PCOS patients and fourteen tubular infertility patients were recruited from patients seeking reproductive assistance at The Center of Reproductive Medicine in Taiyuan, China. Each patient went through an in vitro fertilization and embryo transplantation (IVF-ET) procedure. The mRNA and protein levels of hormones, hormo.. View More»
