Xianming Ning
China
Research Article
The Association between Vitamin D Receptor FokI Gene Polymorphism and Osteoporosis in Postmenopausal Women: A Meta-Analysis
Author(s): Jihong Zhang, Zhipeng Ai, Xianming Ning, Hong Liu, Wenru Tang and Ying LuoJihong Zhang, Zhipeng Ai, Xianming Ning, Hong Liu, Wenru Tang and Ying Luo
Objective: The aim of this study was to quantitatively summarize the evidence for VDR FokI gene polymorphism and osteoporosis risk in postmenopausal women.
Materials and methods: Electronic search at PubMed, EMBASE, Weipu database, and Wanfang database was conducted to select studies. Case-control studies containing available genotype frequencies of F/f were chosen, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this revelance.
Results: The case-control studies including 2199 osteoporosis cases and 2231 controls were identified. Overall meta-analysis indicated that individuals with the homozygous ff genotype had increased risk of osteoporosis(Recessive model: OR=1.551, 95% CI: 1.035~2.325,p=0.034).In the stratified analysis, individuals with the ff genotype in the Recessiv.. View More»
