Oncology & Cancer Case Reports

ISSN - 2471-8556

West M

West M
34 Maple Street, Norwalk Hospital,
Norwalk CT 06856-3815, Yale

  • Case Report
    Adenocarcinoma of the Gallbladder, Proliferative Transformation to Neuroendocrine Tumor: Hypothesis of Molecular and Pathological Etiology
    Author(s): Amar S, Mountjoy L and West MAmar S, Mountjoy L and West M

    Neuroendocrine tumors (NET) of the gallbladder are extremely rare and coexistence with an adenocarcinoma in the same specimen has only rarely been reported. There is a newly defined entity of mixed adenoneuroendocrine carcinoma (both components should be >30%), but not all cases qualify. It is unclear if the NET dedifferentiates into the adenocarcinoma elements or vice versa. We report the case of a woman who presented with non-specific cholecystitis like symptoms and was found to have elements of a high-grade NET of the gallbladder with an area of adenocarcinoma. The prognosis is determined by the high-grade NET element and the patient was treated with surgery followed by concomitant chemo-radiation. The incidence and prevalence of NET ranges from 1.09 per 100,000 individuals over the past 50 years, with a 6.4-fold increase in incidence since 2012. Diagnosis of NET are com.. View More»

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