Virginia M. Miller
Department of Internal Medicine, Mayo Clinic College of Medicine,
Rochester, MN 55905
Research Article
Using Heart Failure with Preserved Ejection Fraction to Understand an Omics Approach to Evaluating Vascular Dysfunction and Cardiovascular Disease
Author(s): Rosita Zakeri, Catalina Vallejo-Giraldo, K. Efua Taylor, Virginia M. Miller and Niccole S. SchaibleRosita Zakeri, Catalina Vallejo-Giraldo, K. Efua Taylor, Virginia M. Miller and Niccole S. Schaible
Regulation of vascular tone is complex due to the presence of redundant mechanisms operating over multiple spatial domains (cell, tissue and organ) and influenced by various confounding factors, such as sex, age and time. As a result, the task of identifying the underlying mechanisms of vascular dysfunction associated with complex cardiovascular diseases, like heart failure with preserved ejection fraction (HFpEF), remains under explored. ‘Omics research strategies are proposed to be an effective way to navigate complicated physiology. In this review an ‘omics approach is applied to the spatial domains of HFpEF using a mechanistic “physiological map” of factors known to be associated with vascular (dys) function. The result is intended to generate hypotheses, foster robust study design, and highlight the necessity for collaborative, interd.. View More»
