Research Article
Concentrations of Ghrelin and Leptin in Children with Cystic Fibrosis
Author(s): Sabina Wiecek, Halina Wos, Bozena Kordys-Darmolinska and Urszula Grzybowska-ChlebowczykSabina Wiecek, Halina Wos, Bozena Kordys-Darmolinska and Urszula Grzybowska-Chlebowczyk
Ghrelin and leptin are peptide hormones which, working antagonistically, regulate the energy balance of the body. Abnormal concentrations of these hormones are observed in the course of gastrointestinal diseases, where the clinical picture is characterized by nutritional disorders. Approximately 70% of patients with cystic fibrosis have body weight deficiency due to exocrine pancreatic insufficiency, respiratory failure, and secondary circulatory disorders as well as eating disorders. The aim of the study was to evaluate the levels of ghrelin and leptin in the blood serum of patients diagnosed with cystic fibrosis, in relation to their nutritional status and function of liver cells. Patients and methods: The study group consisted of 34 patients, 17 girls (50%) and 17 boys (50%), aged from 3 months to 18 years (mean age 4.5 years) who were diagnosed with cystic fibrosis on the basis of sc.. View More»
