Tsuyoshi Shimomura
Deparment of Neurosurgery, Oita University Faculty of Medicine,
Oita, 879-5593
Japan
Research Article
Contralateral Negative Bold Responses in the Motor Network during Subthreshold High-Frequency Interleaved Tms-Fmri over the Human Primary Motor Cortex
Author(s): Tsuyoshi Shimomura, Minoru Fujiki, Hiroshi Ohba, Takanori Kochiyma, Kenji Sugita, Hiroyuki Matsuta, Yukari Kawasaki, Kohei Oonishi, Hirotaka Fudaba and Thoru KamidaTsuyoshi Shimomura, Minoru Fujiki, Hiroshi Ohba, Takanori Kochiyma, Kenji Sugita, Hiroyuki Matsuta, Yukari Kawasaki, Kohei Oonishi, Hirotaka Fudaba and Thoru Kamida
Objective: Transcranial Magnetic Stimulation (TMS) is a noninvasive technique that stimulates a localized brain region underneath a coil. Recently, the application of repetitive Transcranial Magnetic Stimulation (rTMS) to the primary motor cortex (M1) has been used to promote functional recovery in stroke patients with hemiparesis. High-frequency rTMS (5 Hz or greater) was applied over the affected hemisphere to reactivate hypoactive regions. Because of recent advances in MRI technology and, in particular, the gradient coils, high-frequency whole brain rTMS-fMRI is possible. The use of interleaved rTMS-fMRI during stimulation at a frequency of 5 Hz aids in understanding how the brain is modulated during stimulation.
Method: We measured BOLD signal changes in whole brain during interleaved rTMS-fMRI (5Hz) using 3T MRI. Image processing and st.. View More»
