Tomoaki Matsumoto
Japan
Research Article
Neural Stem and Progenitor Cells with High Proliferation Potential in
Injured Areas in a Model of Neonatal Hypoxic-Ischemic Encephalopathy
Author(s): Jun Kido and Tomoaki MatsumotoJun Kido and Tomoaki Matsumoto
Objective: Neonatal hypoxic-ischemic encephalopathy causes death and severe neurological sequelae including cerebral palsy, epilepsy, and mental retardation. Because hypothermia therapy is the only effective treatment for neonatal hypoxic-ischemic encephalopathy and its efficacy is limited in severe cases, a more effective treatment is needed. Neural stem and progenitor cells are important for neuroprotection and neuronal replacement following hypoxic-ischemic encephalopathy. The aim of this study was to confirm the presence of neural stem cells and the acceleration of their mitotic activity in injured areas in a model of neonatal hypoxic-ischemic encephalopathy.
Method: Hypoxic-ischemic encephalopathy was induced in rat pups by left common carotid artery occlusion followed by hypoxia. Following ischemic injury, brains were sectioned, and colum.. View More»
