Tobias von Wild
Germany
Research Article
New Aspects of Graft-induced Central Plasticity and Neuroregeneration at T 10 in a Rat Modelâ€
Author(s): Klaus RH von Wild, Catoi C, Tobias von Wild, Giorgio Brunelli, Dafin Muresanu, Peter Trillenberg, Marc Heidbreder, Laura Farcas, Adrian F Gal, Marian A Taulescu, Alexandru I Gudea, Johannes C Vester and Marlene LöhnhardtKlaus RH von Wild, Catoi C, Tobias von Wild, Giorgio Brunelli, Dafin Muresanu, Peter Trillenberg, Marc Heidbreder, Laura Farcas, Adrian F Gal, Marian A Taulescu, Alexandru I Gudea, Johannes C Vester and Marlene Löhnhardt
Objective: Retest Brunelli’s graft induced glutamate neurotransmitter switch at the neuromuscular junction in rat for the translation of new aspects of central plasticity concepts for human reconstructive surgery in spinal cord lesions.
Methods: Randomized double blind controlled study in rat, which was limited to 30 animals (Charles River, 220 to 280 g). Ethical research approval was obtained from the Animal Research Committee of the University Hospital Schleswig Holstein, UK-SH, Lübeck, D, and legitimated by the Governmental Department of Agriculture, Natural Environments and Agriculture Kiel, D, in compliance with the European Commission Recommendation to retest and review of graft-induced glutamatergic regeneration and /or cholinergic co-transmission at the neuromuscular junction for reinnervation of the skeletal obliquus abdomi.. View More»
