Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Takako Takemiya
Medical Research Institute, Tokyo Women’sMedical University,
Shinjuku, Tokyo, 162-8666
Japan
Research Article
Potential Roles of Prostaglandin E2 and Interleukin-1? in Experimental Autoimmune Encephalomyelitis
Author(s): Takako TakemiyaTakako Takemiya
Multiple sclerosis (MS) is a progressive disease that is characterized by multifocal inflammation and demyelination in a central nervous system. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that shows ascending flaccid paralysis with inflammation of spinal cord. We focus on the potential roles of inducible prostaglandin E2 (PGE2) and interleukin-1β (IL-1β) in EAE after myelin oligodendrocyte glycoprotein 35-55 peptide immunization in this review. PGE2 synthesized by cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1 (mPGES-1) in vascular endothelial cells (VECs) or macrophages/microglia aggravates inflammation, demyelination and paralysis and facilitates the activation and differentiation of CD4-positive (CD4+) T cells into interleukin-17 (IL-17)-producing helper T cells to promote neuronal dysfunction and blood-spinal cord barrier d.. View More»
