Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Research Article
Event Related Brain Potentials (ERP) Could Not Assess the Risk of Cognitive Impairment in Relapse-Remitting Multiple Sclerosis (RRMS)
Author(s): Svetlana Miletic Drakulic, Ana Vujic, Ana Azanjac Arsic, Snezana Lazarevic, Jasna Jevdjic and Dejan Z. AleksicSvetlana Miletic Drakulic, Ana Vujic, Ana Azanjac Arsic, Snezana Lazarevic, Jasna Jevdjic and Dejan Z. Aleksic
Objectives: The first objective of our study was to determine differences between groups of patients receiving disease modifying therapy (DMTs) (INFβ-1a and INFβ-1b), patients without DMTs and a control group, in terms of neuropsychological tests and event-related brain potentials (ERP). The second objective was to determine factors that may serve to assess the risk of cognitive impairment in patients with relapsing remitting multiple sclerosis (RRMS).
Methods: A total of 81 RRMS patients (mean age 41.09 ± 8.71 years old, 51 women, mean disease duration 133.05 ± 76.56 months) and 32 healthy controls participated in the study. Cognitive functions were evaluated using a standard PASAT-3, the symbol digit modality test (SDMT) and ERP.
Results: There were statistically significant differences between the mean values for parietal (Pz) (p ≤ 0.05) and ce.. View More»
