Medical Reports & Case Studies

ISSN - 2572-5130

Souvik Choudhuri

  • Case Report
    Relief of Acute Chest Syndrome of Sickle Cell Anaemia by Nitric Oxide Inhalation - A Report of 2 Cases
    Author(s): Souvik Choudhuri, Banambar Ray and Dipika MohantySouvik Choudhuri, Banambar Ray and Dipika Mohanty

    Depletion of nitric oxide (NO) in the microcirculation plays a central role in the pathogenesis of sickle cell disease (SCD) and acute chest syndrome (ACS). Various other mechanisms which are responsible for the sickle-cell vasoocclusive crisis are polymerization of sickle haemoglobin, platelet activation, endothelial damage and leucocyte adhesion. During the sickle cell crisis, the high rate of red blood cell (RBC) destruction leads to release of erythrocyte arginase (into the plasma), which thereby destroys arginine. Arginine, the substrate for NO synthase, once depleted, results in lower levels of NO in vessels, leading to vasoconstriction, pulmonary hypertension and ventilation perfusion mismatch. Increasing the availability of NO therefore has a central role in SCD, especially in cases of ACS. With the prevention of vasoconstriction by NO inhalation therapy in ACS, pain relief ca.. View More»

    DOI: 10.4172/2572-5130.1000156

    Abstract PDF

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