Slawomir Michalak
Department of Neurochemistry and Neuropathology,
60-355 Poznan, Przybyszewskiego str. 49
Poland
Research Article
The Effect of Methylprednisolone, Interferon Beta and Glatiramer Acetate Treatment on the Levels of Leptin, Adiponectin and Resistin in Multiple Sclerosis Patients
Author(s): Slawomir Michalak, Lukasz Jernas, Ewa Wysocka, Krystyna Osztynowicz, Elzbieta Tokarz-Kupczyk, Halina Wygladalska-Jernas and Wojciech KozubskiSlawomir Michalak, Lukasz Jernas, Ewa Wysocka, Krystyna Osztynowicz, Elzbieta Tokarz-Kupczyk, Halina Wygladalska-Jernas and Wojciech Kozubski
Objective: Adipocytokines are cytokine-like mediators that link adipose tissue function with inflammatory and
autoimmune processes, and have a suggested role in the pathogenesis of multiple sclerosis (MS). The aim of this
study was to analyze the effects of methylprednisolone, interferon-1b (INF) and glatiramer acetate (GA) on leptin,
resistin, and adiponectin concentrations in relapsing-remitting MS (RRMS) patients.
Methods: The study included 154 RRMS patients who were hospitalized in the Department of Neurology, Poznan
University of Medical Sciences. The comparison group included 31 patients with myasthenia gravis (MG) and 39
healthy controls. Serum levels of leptin, adiponectin, and resistin were evaluated before treatment initiation. In the
RRMS patients treated with methylprednisolone, adipocytokine evaluation was performed one da.. View More»
