Siamak P Nejad-Davarani
Tanzania
Research Article
Perfusion and Diffusion Abnormalities of Multiple Sclerosis Lesions and Relevance of Classified Lesions to Disease Status
Author(s): Lian Li, Michael Chopp, Siamak P Nejad-Davarani, Kourosh Jafari-Khouzani, Suresh C Patel, John Budaj, Mei Lu, Stanton B Elias, Mirela Cerghet and Quan JiangLian Li, Michael Chopp, Siamak P Nejad-Davarani, Kourosh Jafari-Khouzani, Suresh C Patel, John Budaj, Mei Lu, Stanton B Elias, Mirela Cerghet and Quan Jiang
Objective
Hemodynamic abnormality and disruption of white matter (WM) integrity are significant components in the
pathophysiology of multiple sclerosis (MS) lesions. However, the roles of stratified lesions with distinct degrees of
hemodynamic and structural injury in disease states remain to be explored. We tested the hypothesis that
hemodynamic and structural impairment, as assessed by cerebral blood volume (CBV) and fractional anisotropy
(FA), respectively, characterizes the extent of tissue injury, and the load of lesion with substantial tissue destruction
would reflect the disease status and therefore, would be related to clinical disability.
Methods
Seven relapsing-remitting MS patients and seven healthy controls underwent perfusion, diffusion and
conventional MRI scans. Based on T2-FLAIR and T1-weighted image, WM pl.. View More»
