Shu-Chuan Wu
People's Republic of China
Research Article
Parecoxib, A Selective Cyclooxygenase Inhibitor, Attenuates C-Jun N-Terminal
Kinase Activation in Experimental Subarachnoid Hemorrhage Induced Early
Brain Injury
Author(s): Chih-Zen Chang, Shu-Chuan Wu, Chih-Lung Lin and Aij-Lie KwanChih-Zen Chang, Shu-Chuan Wu, Chih-Lung Lin and Aij-Lie Kwan
Background: Increased evidence has disclosed early brain injury (EBI) might determine the outcome of patients
suffering from aneurismal subarachnoid hemorrhage (SAH). This study is of interest to examine the efficacy of
parecoxib, a cyclooxygenase-2(COX-2) inhibitor, on SAH-induced EBI.
Methods: The rodent SAH model was employed. 500/1000/2000ug/kg/day parecoxib was administered via
osmotic mini-pump. CSF samples were collected to examine IL-1β, IL-6, IL-8 and TNF-α. Cerebral cortex was
harvested for C-Jun N-terminal kinase (cJNK), NMDARs (western blot), B-cell lymphoma 2 (Bcl-2), caspases (rt-
PCR) measurement.
Results: Parecoxib dose-dependently reduced the bio-expression of cJNK when compared with the SAH groups.
No significant differences were found in the levels of IL-8 among the experimental groups. The levels of.. View More»
