Savelberg HH
England
Research Article
Effects of Exercise Intensity in Experimental Autoimmune Encephalomyelitis
Author(s): Wens I, Broekmans T, Hendriks JJA, Savelberg HH, Hesselink MK and Eijnde BOWens I, Broekmans T, Hendriks JJA, Savelberg HH, Hesselink MK and Eijnde BO
Background: Research on muscle contractile properties and disease progression following experimental autoimmune encephalomyelitis (EAE) and physical exercise remains conflicting.
Objective: To investigate the effect of different exercise intensities on muscle contractile properties and hindquarter paralysis during EAE in Lewis rats.
Methods: A control and EAE group were divided in sedentary, light, moderate and high intensity running subgroups. During EAE course, hind limb paralysis, body weight and food intake were registered. Following EAE recovery isokinetic foot extensor strength was measured during 115 maximal contractions and fiber characteristics of m. tibialis anterior (TA) and m. extensor digitorum longus (EDL) were analysed.
Results: EAE reduced CSA of type IIb+x fibers of TA and EDL,.. Read More»
