Satoshi Kikuchi
Japan
Research Article
Effects of Dexamethasone on Pulmonary Oxygenation Impairments in Therapeutic Hypothermia for Patients with Traumatic Brain Injury
Author(s): Mayuki Aibiki, Kensuke Umakoshi, Saori Ohtsubo, Satoshi Kikuchi, Hironori Matsumoto, Muneaki Ohshita, Soichi Maekawa and Takashi NishiyamaMayuki Aibiki, Kensuke Umakoshi, Saori Ohtsubo, Satoshi Kikuchi, Hironori Matsumoto, Muneaki Ohshita, Soichi Maekawa and Takashi Nishiyama
Objectives: We studied retrospectively to examine differences in the occurrence rate of pneumonia and the
time-course changes in pulmonary oxygenation between hypothermic and normothermic therapies with or without
dexamethasone (D) administration in patients with traumatic brain injury (TBI).
Design: A retrospective observational study.
Setting: Two university hospitals.
Subjects and Methods: In consecutive TBI patients (GCS ≤ 8) treated with hypothermic (N=23, 32-33°C) or
normothermic (N=16, 36-37.5°C) therapy, the occurrence rate of pneumonia, PaO2/FIO2 (P/F) ratios and C-reactive
protein (CRP) levels were examined. The comparisons were made among hypothermic and normothermic groups
with or without D administration. In several patients in both groups, neutrophil functions were examined. Data were
analyzed with.. View More»
