Ponnada A. Narayana
Tanzania
Research Article
Association of Multiple Sclerosis Related Cognitive Impairment with an MRIDerived Composite Score
Author(s): Flavia Nelson, Aziz H. Poonawalla, Sushmita Datta, Rosa C. Banuelos, Mohammad H. Rahbar, Francisco Perez, Jerry S. Wolinsky and Ponnada A. NarayanaFlavia Nelson, Aziz H. Poonawalla, Sushmita Datta, Rosa C. Banuelos, Mohammad H. Rahbar, Francisco Perez, Jerry S. Wolinsky and Ponnada A. Narayana
Background: MRI-derived metrics such as atrophy, burden of disease (BOD), and cortical lesions (CL) have independently been reported to be associated with Multiple Sclerosis (MS) related cognitive impairment (CI). Composite scores combining some of these individual metrics have also been shown to improve correlations with MS-related physical disability; however the value of a composite score for MS-related CI has not yet been evaluated. In this study we assessed the relationship between CI and a quantitative composite score constructed from MRIderived metrics to include total white matter lesion volume, CL number, and normalized cerebrospinal fluid (nCSF), a measure of brain atrophy.
Methods: Thirty three (n=33) patients underwent neuropsychological testing and were classified into CI groups using a 4-point severity scale (0, 1, 2, 3) where .. Read More»
