Noriyuki Okonogi
Japan
Review Article
Current Advances in Radiotherapy for Newly Diagnosed Glioblastoma Multiforme
Author(s): Noriyuki Okonogi, Takahiro Oike, Katsuyuki Shirai, Tomoaki Tamaki, Shin-ei Noda, Yoshiyuki Suzuki and Takashi NakanoNoriyuki Okonogi, Takahiro Oike, Katsuyuki Shirai, Tomoaki Tamaki, Shin-ei Noda, Yoshiyuki Suzuki and Takashi Nakano
Glioblastoma multiforme is the most common adult primary brain tumor that is associated with very poor
survival. The current standard therapy for newly diagnosed glioblastoma multiforme includes surgical resection and
a combination of radiotherapy and chemotherapy with temozolomide. This treatment strategy leads to better overall
survival; however, majority of tumor recurrences occur within the irradiated field. To overcome this problem, dose
intensification is being tested in the management of glioblastoma multiforme.
In recent years, technological development of radiotherapies, such as intensity-modulated radiation therapy,
stereotactic radio surgery, stereotactic radiation therapy, boron neutron capture therapy, and particle beam therapy,
has improved dose distribution. Several prospective studies using these radiotherapies have show.. View More»
