Neil Lava
Tanzania
Research Article
Blood B Cell and Regulatory Subset Content in Multiple Sclerosis Patients
Author(s): Jakob Habib, Jiusheng Deng, Neil Lava, William Tyor and Jacques GalipeauJakob Habib, Jiusheng Deng, Neil Lava, William Tyor and Jacques Galipeau
Objective: B cell targeted therapies have been effective in slowing multiple sclerosis (MS) disease progression suggesting a direct causal link for this lymphoid subset. A small subset of B cells with regulative properties (Bregs) exists in peripheral blood, and induction of Bregs ameliorates experimental autoimmune encephalomyelitis (EAE), the murine model for MS. Therefore the frequency of B cell subsets and regulatory B cells in particular in peripheral blood of MS patients is of interest.
Methods: The phenotype and frequency of B cell subsets in peripheral blood from 32 MS patients and 34 healthy controls (HC) were examined using flow cytometry.
Results: We found that there is an increase in CD19+ cell number in MS 1347 ± 159 cells/μL, (average ± SEM) compared to HC, 935 ± 129 cells/μ.. Read More»
