Moretti D V
IRCCS Giovanni di Dio Fatebenefratelli,
Brescia
Italy
Research Article
Temporo-Parietal Brain Network Impairment Is Related To EEG ALPHA3/ALPHA2 Frequency Power Ratio in Prodormal Alzheimer's Disease
Author(s): Moretti D V, Paternicò D, Binetti G, Zanetti O and Frisoni G BMoretti D V, Paternicò D, Binetti G, Zanetti O and Frisoni G B
Background: Reliable biomarkers are the new frontier for an early diagnosis of Alzheimer's disease and to monitor therapeutic options Objective: Volume reduction in temporo-parietal network is associated to mild cognitive impairment (MCI) due to Alzheimer disease (AD). The increase of EEG alpha3/alpha2 ratio has been associated with AD-converter MCI subjects. We investigated the association of alpha3/alpha2 ratio with patterns of cortical thickness in MCI. Methods: 74 adult subjects with MCI underwent clinical and neuropsychological evaluation, electroencephalogram (EEG) recording and high resolution 3D magnetic resonance imaging (MRI). Alpha3/alpha2 power ratio as well as cortical thickness was computed for each subject. Three MCI groups were detected according to increasing tertile values of alpha3/alpha2 and difference of cortical thikness among the groups estimated. Pearson&rs.. View More»
