Michael J Betenbaugh
Tanzania
Research Article
Towards Integrative Glycoinformatics for Glycan Based Biomarker Cancer Research and Discovery
Author(s): Sandra V Bennun, Deniz Baycin Hizal, René Ranzinger and Michael J BetenbaughSandra V Bennun, Deniz Baycin Hizal, René Ranzinger and Michael J Betenbaugh
Despite some recent successes in deciphering new cancer molecular makers, there is still a clear and continual need to develop new technologies that help characterizing existing biomarkers or facilitate discovery of new biomarkers. An important systems biology opportunity on this respect is provided by understanding the glycosylation changes associated with cancer. Indeed, interest in cancer glycosylation has expanded over the past decade and large amount of data relevant to cancer glycosylation has been accumulating rapidly. Furthermore, new and improved sophisticated glycoinformatics tools, methods and databases for glycan analysis now offer the opportunity to investigate this data for understanding the role that glycans play in cancer glycosylation. Here we summarize developments of glycoinformatics tools to support analysis of cancer glycosylation and experimental glycoproteomics .. View More»
