Michael Chopp
Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA
Dr.Michael Chopp did his Ph.D from New York University in 1975. He did his master degree in M.S. Physics from New York University, New York, in 1970. He did his bachelor degree B.S. Physics, Brooklyn College, Brooklyn in 1967
Dr.Michael Chopp's Awards, Honors and Publications
Honors
Distinguished Scientist Award, Henry Ford Medical Group—Board of Governors, 2005
American Heart Association—Top Ten Research Advances of 2001
Treatment of Stroke with Bone Marrow Stromal Cells
272 Plenary Lectures/Invited Presentations
Selected Peer Reviewed Journal Articles
Lu D, Mahmood A, Qu C, Goussev A, Xiong Ye, Jiang F, Hong X, Zhang XP, Mauney J, Volloch V, Kaplan D, Chopp M. Collagen scaffolds populated with human marrow stromal cells reduce lesion volume and improve functional outcome after traumatic brain injury. Neurosurgery 2007;61(3):596-602; discussion 602-603. PMID:17899689
Zacharek A, Chen J, Cui X, Ang L, Li Y, Roberts C, Gao Q, Yifan F, Chopp M. Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. J Cereb Blood Flow Metab 2007;27(10):1684-1691. PMID:17356562
Zhang X, Jiang F, Kalkanis SN, Zhang ZG, Hong X, Yang HY, Chopp M. Post-acute response of 9L gliosarcoma to Photofrin™ mediated PDT in athymic athymic nude mice. J Lasers Med Science 2007;22(4):253-259. PMID:17505777
Mahmood A, Lu D, Qu C, Goussev A, Zhang ZG, Lu C, Chopp M. Treatment of traumatic brain injury in rats with erythropoietin and carbamylated erythropoietin. J Neurosurg 2007;107(2):392-397. PMID:17695395
Zhang RL, Zhang ZG, Chopp M. Gene profiles within the adult subventricular zone niche proliferation, differentiation and migration of neural progenitor cells in the ischemic brain. Curr Mol Med 2007;7(5):459-462. PMID:17691960
Shen L, Li Y, Chen J, Cui Y, Zhang C, Kapke A, Lu M, Savant-Bhonsale S, Chopp M. One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke. Stroke 2007;37(7):2150-2156. PMID:17525391
Zhang L, Zhang ZG, Liu XS, Hozeska-Solgot A, Chopp M. The PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the rat. Arterioscl Thromb Vas Biol 2007;27(11):2470-2475. PMID:17717296
Wang L, Zhang ZG, Gregg SR, Zhang RL, Jiao ZX, LeTourneau Y, Liu XS, Teng H, Feng Y, Gerwien J, Torup L, Leist M, Chopp M. The sonic hedgehog pathway mediated carbamylated EPO enhanced proliferation and differentiation of adult neural progenitor cells. J Biol Chem 2007;282(44):32462-32470. PMID:17804404
Cui X, Chen J, Zacharek A, Roberts C, Kapke A, Savant-Bhonsale S, Chopp M. Nitric oxide donor upregulation of SDF1/CXCR4 enhances BMSC migration into ischemic brain after stroke. Stem Cells 2007;25(11):2777-2785. PMID:17641243
Xiong Y, Mahmood A, Lu D, Qu C, Goussev A, Schallert T, Chopp M. Role of gender in outcome after traumatic brain injury and therapeutic effect of erythropoietin in mice. Brain Res 2007;1185:301-312. PMID:17976541
Wang Y, Zhang ZG, Rhodes K, Renzi M, Zhang RL, Kapke A, Lu M, Pool C, Heavner G, Chopp M. Post-ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia. Br J Pharmacol 2007;151(8):1141-1142. PMID:17603558
Chen J, Zacharek A, Cui X, Li A, Roberts C, Lu M, Chopp M. Atorvastatin promotes presenilin1 expression and notch1 activity and increases neural progenitor cell proliferation after stroke. Stroke 2008; 39(1):220-226. PMID:18063826
Lu M, Zhang RL, Zhang ZG, Chopp M. The linkage of neural progenitor cell cycle profiles between embryonic and adult stroke models: Analytical approach II. J Neurosci Meth 2008;167(2):376-383. PMID:17928064
Lui Z, Li Y, Zhang J, Elias SB, Chopp M. Evaluation of corticospinal axon loss by fluorescent dye tracing in mice with experimental autoimmune encephalomyelitis. J Neurosci Meth 2008;167(2):191-197. PMID:17919735
Wu H, Lu D, Jiang H, Xiong Y, Qu C, Li B, Mahmood A, Zhou D, Chopp M. Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury. J Neurotrauma 2008;25(2):130-139. PMID:18260796
Zhang RL, Zhang ZG, Roberts C, LeTourneau Y, Lu M, Wang Y, Chopp M. Lengthening the G1 phase of neural progenitor cells is concurrent with switching from symmetric proliferation to symmetric neuron generating division after stroke. J Cerebral Blood Flow Metab 2008;28(3):602-611. PMID:17928800
Gao Q, Li Y, Shen LH, Zhang J, Zheng X, Liu Z, Chopp M. Bone marrow stromal cells reduce ischemia-induced astrocytic activation in vitro. Neuroscience 2008;152(3):646-655. PMID:18313231
Teng H, Zhang ZG, Wang L, Zhang RL, Zhang L, Morris D, Gregg SR, Wu Z, Jiang A, Lu M, Zlokovic BV, Chopp M. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab 2008;28(4):764-771. PMID:17971789
Santra M, Santra S, Zhang J, Chopp M. Ectopic decorin expression upregulates VEGF expression in mouse cerebral endothelial cells via activation of Sp1, HIF1alpha, and Stat3 the transcription factors. J Neurochem 2008;105:324-337. PMID:18021292
Qu C, Mahmood A, Lu D, Goussev A, Xiong Y, Chopp M. Treatment of traumatic brain injury in mice with marrow stromal cells. Brain Res 2008;1208:234-239. PMID:18384759
Ding G, Jiang Q, Li L, Zhang L, Zhang ZG, Ledbetter KA, Gollopalli L, Panda S, Li QJ, Ewing JR, Chopp M. Angiogenesis detected post embolic stroke in rat brain using magnetic resonance T2*WI. Stroke 2008;39:1563-1568. PMID:18356548
Zhang J, Li Y, Zheng X, Gao Q, Liu Z, Qu R, Borneman J, Elias SB, Chopp M. Bone marrow stromal cells protect oligodendrocytes from oxygen-glucose deprivation injury. J Neurosci Res 2008;86(7):1501-1510. PMID:18214988
Kwon DS, Gao X, Liu YB, Dulchavsky DS, Danyluk AL, Bansal M, Chopp M, McIntosh K, Arbab AS, Dulchavsky SA, Gautam SC. Treatment with bone marrow-derived stromal cells accelerates wound healing in diabetic rats. Int Wound J 2008;5(3):453-463. PMID:18593394
Borlongan CV, Chopp M, Steinberg GK, Bliss TM, Li Y, Lu M, Hess DC, Kondziolka D. Potential of stem/progenitor cells in treating stroke: the missing steps in translating cell therapy from laboratory to clinic. Regen Med. 2008;3(3):249-50. PMID:18462048
Silver B, Lu M, Morris DC, Mitsias PD, Lewandowski CA, Chopp M. Blood pressure declines and less favorable outcomes in the NINDS tPA stroke study. J Neurol Sci 2008 271(1-2):61-67. PMID:18455192
Wang L, Zhang ZG, Gregg SA, Zhang RL, Teng H, Jiang A, Feng Y, Chopp M. Neural progenitor cells treated with EPO induce angiogenesis via the production of VEGF. J Cereb Blood Flow Metab 2008;28(7):1361-1368. PMID:18414495
Zhang RL, Zhang ZG, Chopp M. Ischemic stroke and neurogenesis in the subventricular zone. J Neuropharm 2008 55(3):345-352. PMID:18632119
Liu Z, Li Y, Zhang X, Savant-Bhonsale S, Chopp M. Contralesional axonal remodeling of the cortico-spinal system in adult rats following stroke and bone marrow stromal cell treatment. Stroke 2008;39:2571-2577. PMID:18617661
Knight RA, Han Y, Nagaraja TN, Whitton P, Ding J, Chopp M, Seyfried DM. Temporal MRI assessment of intercerebral hemorrhage in rats. Stroke 2008;39:2596-2602. PMID:18635862
Ding G, Jiang Q, Li L, Zhang L, Zhang ZG, Ledbetter KA, Panda S, Davarani SP, Athiraman H, Li Q, Ewiing JR, Chopp M. Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats. J Cereb Blood Flow Metab 2008;28:1440-1448. PMID:18418368
Seyfried DM, Han Y, Yang D, Ding J, Savant-Bhonsale S, Shukairy MS, Chopp M. Mannitol enhances delivery of marrow stromal cells to the brain after experimental intracerebral hemorrhage. Brain Res 2008;1224:12-19. PMID:18573239
Wu H, Lu D, Jiang H, Xiong Y, Qu CS, Li B, Zhou D, Mahmood A, Chopp M. Simvastatin increases phosphorylation of Akt and its downstream signaling targets and suppresses apoptosis after traumatic brain injury. J Neurosurg 2008;25(2):130-139. PMID:18260796
Liu XS, Zhang ZG, Santra M, Hozeska-Solgot A, Zhang RL, Wang L, Teng H, Chopp M. Functional response to SDF!? through over-expression of CXCR4 on adult subventricular zone progenitor cells. Brain Res 2008;126:18-26. PMID:18598677
Xiong Y, Lu D, Qu Q, Goussev A, Schallert T, Mahmood A, Chopp M. Effects of erythropoietin on reducing brain damage and improves functional outcome following traumatic brain injury in mice. J Neurosurg 2008;109(3):510-521. PMID:18759585
Zhang RL, Zhang C, Zhang L, Roberts C, Lu M, Kapke A, Cui Y, Ninomiya M, Nagafuji T, Zhang ZG, Albala B, Chopp M. Synergistic effect of an endothelin type A receptor antagonist, S-01139, with rtPA on the neuroprotection after embolic stroke. Stroke 2008;39(10):2830-2836. PMID:18669895
Cui X, Chen J, Zacharek A, Roberts C, Lu M, Savant-Bhonsale S, Chopp M. Treatment of stroke with DETA-NONOate and bone marrow stromal cells upregulates angiopoietin1/Tie2 and enhances neovascularization. Neuroscience 2008;156(1):155-164. PMID:18691637
Xiong Y, Mahmood A, Lu D, Qu C, Kazmi H, Goussev A, Zhang ZG, Noguchi CT, Schallert T, Chopp M. Histological and functional outcomes after traumatic brain injury in mice null for the erythropoietin receptor in the central nervous system. Brain Res 2008;1230:247-257. PMID:18657521
Chopp M Li Y, Zhang J. Plasticity and remodeling of brain. J Neurol Sci 2008;265(1-2):97-101. PMID:1761-0903
Chen J, Cui X, Zacharek A, Chopp M. Increasing Ang1/Tie2 expression by simvastatin treatment induces vascular stabilization and neuroblast migration after stroke. J Cell Mol Med 2008 (in press). PMID:18544044
Shen LH, Li Y, Gao, Q, Savant-Bhonsale S, Chopp M. Down-regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain. GLIA 2008 (in press). PMID:18618668
Zacharek A, Chen J, Cui X, Yang Y, Chopp M. Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. Stroke 2008 (in press). PMID:18927449
Wu H, Lu D, Jiang H, Xiong Y, Qu Changsheng, Li B, Mahmood A, Zhou D, Chopp M. Increase in phosphorylation of Akt and its downstream signaling targets and suppresses of apoptosis by simvastatin after traumatic brain injury. J Neurosurg 2008 (in press). PMID:18826357
Cui X, Chen J, Zacharek A, Roberts C, Yang Y, Chopp M. Nitric oxide donor upregulation of SDF1/ CXCR4 and Ang1/Tie2 promotes neuroblast cell migration after stroke. J Neurosci Res 2008 (in press). PMID:18711749
Zhang J, Chen J, Li Y, Cui X, Zheng X, Roberts C, Lu M, Elias SB, Chopp M. Niaspan treatment improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. Neurobiol Dis 2008 (in press). PMID:18778774
Bosomtwi A, Jiang Q, Ding GL, Zhang L, Zhang ZG, Lu M, Ewing JR, Chopp M. Quantitative evaluation of microvascular density after stroke in rats using MRI. J Cereb Blood Flow Metab 2008 (in press). PMID:18766197
Liu XS, Chopp M, Zhang X, Buller B, Zhang RL, Hozeska-Solgot A, Gregg SR, Zhang ZG. Gene profiles and electrophysiology of doublecortin-expressing cells in the subventricular zone after ischemic stroke. J Cerebral Blood Flow Metab 2008 (in press). PMID:18854839
Chopp M, Li Y, Zheng ZG. Mechanisms underlying improved recovery of neurological function after stroke in the rodent after treatment with neurorestorative cell-based therapies. Stroke 2008 (in press).
Mahmood A, Goussev A, Lu D, Qu C, Xiong Y, Kazmi H, Chopp M. Long-lasting benefits after treatment of traumatic brain injury (TBI) in rats with combination therapy of marrow stromal cells (MSCs) and simvastatin. J Neurotrauma 2008 (in press).
Athiraman K, Jiang Q, Ding GL, Zhang L, Zhang ZG, Wang L, Arbab AS, Li Q, Panda S, Ledbetter K, Chopp M. Investigation of relationships between transverse relaxation rate, diffusion coefficient, and labeled cell concentration in ischemic rat brain using MRI. Magn Reson Imag 2008 (in press).
Wang L, Chopp M, Zhang RL, Zhang L, LeTourneau Y, Feng YF, Jiang A, Morris DC, Zhang ZG. The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke. Neuroscience 2008 (in press).
CANCER ARTICLES
Zheng X, Jiang F, Katakowski M, Zhang X, Jiang H, Zhang ZG, Chopp M. Sensitization of cerebral tissue in nude mice with photodynamic therapy induces ADAM17/TACE and promotes glioma cell invasion. Cancer Lett 2008;265(2):177-187. PMID:1835-8600
Jiang F, Zhang X, Kalkanis SN, Zhang Z, Yang H, Katakowski M, Hong X, Zheng X, Zhu Z, Chopp M. Combination therapy with antiangiogenic treatment and photodynamic therapy for the nude mouse bearing U87 glioblastoma. Photochem Photobiol 2008;84(1):128-137. PMID:18173712
Hong X, Jiang F, Kalkanis SN, Zhang ZG, Zhang X, Zheng X, Mikkelsen T, Chopp M. Increased chemotactic migration and growth in Heparanase-overexpressing human U251n glioma cells. J Exp Clin Cancer Res 2008;27:23 (PubMed – In process). PMID:18647407
