Melanie Kirchmeyer
Luxembourg
Research Article
The Chemokine (C-X3-C Motif) Receptor 1 is a Candidate Prognostic Biomarker after Cardiac Arrest
Author(s): Pascal Stammet, Melanie Kirchmeyer, Lu Zhang, Daniel R. Wagner and Yvan DevauxPascal Stammet, Melanie Kirchmeyer, Lu Zhang, Daniel R. Wagner and Yvan Devaux
Background: Early prediction of outcome after cardiac arrest (CA) may influence treatment strategies. Existing biomarkers are of limited value. Therefore, we sought to determine whether analysis of the transcriptome of circulating blood cells may help to predict outcome after CA.
Methods: Consecutive comatose patients resuscitated after CA and treated with hypothermia were enrolled in this study. Blood samples were drawn 48 hours after CA for gene expression analyses by microarrays and quantitative PCR. Neurological outcome at 6 months was evaluated using the cerebral performance category (CPC). Patients with CPC 1-2 were considered having favorable neurological outcome, whereas patients with CPC 3-5 were considered as having poor outcome.
Results: The initial cohort consisted of 35 patients. Microarrays revealed a biosi.. View More»
