Md Sahab Uddin
Department of Pharmacy, Southeast University, Dhaka,
Bangladesh
Review Article
Searching the Linkage between High Fat Diet and Alzheimer's Disease: A Debatable Proof Stand for Ketogenic Diet to Alleviate Symptoms of Alzheimer's Patient with APOE ε4 Allele
Author(s): Md Sahab Uddin, Anamul Haque, Abdullah Al Mamun, Mohammed Ashraful Iqbal, Md Tanvir Kabir, Ram Kamol Rony and Ariful IslamMd Sahab Uddin, Anamul Haque, Abdullah Al Mamun, Mohammed Ashraful Iqbal, Md Tanvir Kabir, Ram Kamol Rony and Ariful Islam
Alzheimer’s disease (AD) is an incurable neurodegenerative form of dementia affecting millions of individuals worldwide. A hallmark of AD is the deregulation of the level of ß-amyloid (Aß) that leads to the appearance of the senile plaques that contain Aß derived from the cleavage of the amyloid precursor protein. Among numerous risk factors for AD, genetic risk factor such as possession of ε4 allele of apolipoprotein E (ApoE4) is considered as a crucial risk factor. Moreover, dietary fat composition has also been concerned as an important factor for AD since cholesterol and blood-brain barrier functions are linked with AD. The primary genetic risk factor is ApoE ε4 allele that encodes one of several proteins responsible for cholesterol transport and it is considered as foremost cholesterol transport proteins in the brain. For the progression of.. View More»
