Are Periventricular Lesions Specific for Multiple Sclerosis?
Author(s): Gianna Casini, Mary Yurashevich, Rohini Vanga, Subasini Dash, Suhayl Dhib-Jalbut, Brian Gerhardstein, Matilde Inglese, Win Toe and Konstantin E BalashovGianna Casini, Mary Yurashevich, Rohini Vanga, Subasini Dash, Suhayl Dhib-Jalbut, Brian Gerhardstein, Matilde Inglese, Win Toe and Konstantin E Balashov
Background: The presence of periventricular lesions (PVL) on MRI scans is part of the revised McDonald multiple sclerosis (MS) diagnostic criteria. However, PVL can be found in other neurological diseases including stroke and migraine. Migraine is highly prevalent in patients with MS. Objective: To determine if PVL are specific for patients with MS compared to stroke and migraine. Methods: We studied patients diagnosed with clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), migraine, and ischemic stroke. The number, location and the volume of PVL were identified on brain MRI scans and analyzed. Results: The number and volume of PVL adjacent to the body and the posterior horn of the lateral ventricles were significantly increased on fluid-attenuated inversion recovery MRI in RRMS compared to migraine. There were.. Read More»