Journal of Multiple Sclerosis

ISSN - 2376-0389

Massimo Pedriali

  • Review Article
    The Pathology of the Internal Jugular Vein in Multiple Sclerosis

    Author(s): Massimo Pedriali and Paolo ZamboniMassimo Pedriali and Paolo Zamboni

    In the last years it has been described a condition named Chronic Cerebrospinal Venous Insufficiency (CCSVI), frequently but not exclusively associated to Multiple Sclerosis (MS), which generated a strong scientific controversy about the epidemiological prevalence and the possible role in the complex, multi-factorial MS ethio-pathogenesis. However, CCSVI description also stimulated a considerable research activity on the extracranial veins. Among the fields of interest, the pathology of the Internal Jugular Veins (IJVs) was deeply investigated by some groups, so improving our knowledge in an underestimated field of MS research. Currently, the available papers clearly show the presence of abnormalities in the IJV wall of MS patient’s respect to control tissue. In the tunica intima a significant derangement and loss of the endothelial cells have been described. Interesti.. Read More»


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