Masaki Ishihara
Japan
Research Article
Randomized Trial of Repetitive Transcranial Magnetic Stimulation for Apathy and Depression in Parkinson's Disease
Author(s): Hiroaki Oguro, Tomonori Nakagawa, Shingo Mitaki, Masaki Ishihara, Keiichi Onoda and Shuhei YamaguchiHiroaki Oguro, Tomonori Nakagawa, Shingo Mitaki, Masaki Ishihara, Keiichi Onoda and Shuhei Yamaguchi
Objective: Repetitive transcranial magnetic stimulation (rTMS) has been reported to improve motor function and depression in Parkinson’s disease (PD) patients, but there has been only one randomized controlled trial for apathy. We evaluated the efficacy of rTMS for apathy and depression in Parkinson’s disease. Methods: Fifteen PD patients received real rTMS (5 Hz, 500 pulses/day) and placebo stimulation over the supplementary motor area (SMA) for each 5 days with total amount of 2500 real pulses and 2500 placebo pulses, using a randomized real-first or placebo-first protocol. The modified apathy scale, the Zung Self-rating Depression Scale (SDS) and Unified Parkinson’s Disease Rating Scale (UPDRS) were used to assess apathy, depression and clinical status before and after each stimulative treatment. Results: Real rTMS improved the apathy score by 3 points (P<0.05).. View More»
