Masaaki Hokama
Japan
Research Article
Gene Expression Profiling and Bioinformatic Analysis of Rabbit Basilar Artery after Experimental Subarachnoid Hemorrhage
Author(s): Yuichiro Kikkawa, Satoshi Matsuo, Masaaki Hokama, Ryota Kurogi, Akira Nakamizo, Masahiro Mizoguchi and Tomio SasakiYuichiro Kikkawa, Satoshi Matsuo, Masaaki Hokama, Ryota Kurogi, Akira Nakamizo, Masahiro Mizoguchi and Tomio Sasaki
Objective: The molecular mechanisms which contribute to the development of vascular events including cerebral
vasospasm after subarachnoid hemorrhage (SAH) in cerebral artery remain to be elucidated. In this study, we
investigated the time course of changes in the gene expression of cerebral artery using rabbit SAH model and
performed bioinformatic analysis of differentially expressed genes.
Methods: Rabbit basilar arteries were harvested on days 3, 5, and 7 after initial hemorrhage. Changes in gene
expression of the rabbit basilar artery were investigated by using Agilent rabbit oligo microarrays and analyzed the
data by Ingenuity Pathway Analysis (IPA).
Results: Among investigated 43,623 genes, 1,121 genes were differentially expressed at least 1 time point. We
found that the number, magnitude of fold change, and gene expressio.. View More»
