Mansoor A Dar
India
Research Article
Effect of Fluoxetine on Motor Recovery after Acute Haemorrhagic Stroke: A
Randomized Trial
Author(s): Irfan Ahmad Shah, Ravouf P Asimi, Yuman Kawoos, Mushtaq A Wani, Maqbool A Wani and Mansoor A DarIrfan Ahmad Shah, Ravouf P Asimi, Yuman Kawoos, Mushtaq A Wani, Maqbool A Wani and Mansoor A Dar
Background: A few clinical trials have suggested that selective serotonin reuptake inhibitors (SSRI’s) enhance motor recovery after stroke but no study has been done in haemorhagic stroke patients. We therefore aimed to investigate whether fluoxetine, an SSRI would enhance motor recovery in patients of haemorrrhagic stroke.
Methods: Patients who had haemorrhagic stroke with hemiplegia or hemiparesis and were aged between 18 years and 80 years were included in this double-blind, placebo-controlled trial. Patients were randomly assigned, in a 1:1 ratio to fluoxetine (20 mg/d, orally) or placebo for 3 months starting 5-10 days after the onset of stroke. All patients also had routine physiotherapy. The primary outcome measure was the change on the FMMS between day 0 and day 90 after the start of the study drug. Results: A tot.. View More»
